From their unusual birth, Mackenzie and Macey Garrison, conjoined twins connected at the pelvis, set out on an incredible life journey. They overcame their early difficulties with fortitude after being separated at the age of 10 months after a difficult 24-hour operation performed by Dr. James Stein. When they and their triplet sister Madeline were adopted by physical therapist Darla Keller, who brought them into her loving home in Iowa along with her three biological kids, their lives soon took yet another dramatic turn.

As they grew up, the Garrison sisters had to balance the particulars of their mobility with the commonplace teenage experiences of driving with friends and working after school. Both Macey and Mackenzie are one-legged and use prosthetics and crutches, yet they lead busy lives that include riding horses. In addition to preserving their strong relationship and mutual friendships, the sisters are examining their unique personalities and future goals while putting more emphasis on their strengths than their weaknesses.